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The integration of all three pathways is proposed to create a complementary pharmacological profile: appetite suppression and improved insulin secretion from GLP-1 and GIP agonism, combined with enhanced energy expenditure and hepatic lipid metabolism from glucagon receptor activation

Tirzepatide (dual GIP and GLP-1 agonist) 4

MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions

For instance, fenfluramine and d-fenfluramine, which are the direct agonists of 5-HT receptors exhibited anti-obesity properties by increasing the release of serotonin in the synaptic cleft