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Lira (GLP-1R) can reduce the occurrence of hepatic steatosis in vivo and in vitro by enhancing autophagy and lipid degradation through the GLP-1R-transcription factor EB (TFEB)-mediated autophagy lysosomal pathway [37]

Pharmacokinetics, safety and tolerability of oral semaglutide in subjects with renal impairment

Micronutrient gaps : Depending on individual labs, adding targeted whole food-based supplements (such as for vitamin D, magnesium, omega-3 fatty acids, etc) to cover deficiencies

According to the FDA's press release it agreed to approve the drug for obesity based on three randomised, double-blind, placebo-controlled trials during which more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received placebo (US FDA 2021)