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LY is a triple agonist that is currently being studied for its strong activity on the glucagon receptor, glucagon-like polypeptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) receptors

However, in hypertensive patients, endothelial function is often compromised, leading to what is known as endothelial dysfunction. Typically, these cells modulate blood vessel dilation and contraction by releasing factors like NO, prostaglandins, and endothelin, thereby stabilizing blood pressure

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