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Nausea Vomiting Diarrhea Constipation Decreased appetite Injection-site reactions Gallbladder events (cholelithiasis, cholecystitis) reported in some Phase 2 participants Increased heart rate Possible pancreatitis (per GLP-1 class data not specifically reported in retatrutide trials) Frequently asked questions Is retatrutide FDA-approved
Recently, the GIP/GLP-1R co-agonist tirzepatide has gone through several randomized controlled trials and was approved by the FDA for T2DM and obesity in 2022 and 2023, respectively