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Ramulus mori (Sangzhi) alkaloids (SZ-A), which has been approved for the treatment of T2DM in China, was also found to alleviate obesity-driven lipid metabolic disorders and inflammation through regulating gut microbiota disorder and its metabolism profiles ( Nicotine is the most abundant alkaloid in tobacco, accounting for about 95% of the total alkaloid content of tobacco, and is also the main psychoactive substance in smoke (Sansone et al., 2023)