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Table of Contents How Tesamorelin and Retatrutide Work in the Body Potential Interactions Between These Two Medicines What the Current Evidence Says About Combined Use Risks and Safety Considerations to Discuss With Your Doctor When Combined Metabolic Treatments May Be Considered Seeking Guidance From a UK Specialist or Prescriber Scientific References Frequently Asked Questions How Tesamorelin and Retatrutide Work in the Body Tesamorelin stimulates pituitary GH release to reduce visceral fat via the GH/IGF-1 axis, whilst retatrutide is a tri-agonist targeting GLP-1, GIP, and glucagon receptors to suppress appetite and improve metabolism

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When semaglutide is injected, it binds to GLP-1 receptors in the brain and digestive system, triggering several weight-loss-supportive effects: Reduces Appetite It signals the brain that you're full, even with smaller portions, helping you eat less without feeling deprived