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In ALC, intrahepatic monocytes/macrophages are markedly expanded while adaptive immune cells, particularly B and plasma cells, are reduced and metabolically altered, consistent with alcohol-driven myeloid dominance and impaired humoral immunity
We revealed that DAF-16 activation is an important factor that mediates the extended lifespan of the glp-1(-) and fem-3(-) mutants, and its forced activation can reverse the shortened lifespan of the mog-3(-) mutant
PloS one 4 , e6221, doi:10.1371/journal.pone.0006221 (2009)
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