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Thyroid hormone synthesis and metabolism lodothyronine Deiodinases (DIO1, DIO2, and DIO3) Iodothyronine deiodinases regulate thyroid hormone levels at plasma level (DIO1) as well as at tissue and cellular level, converting thyroxine, T 4 , to the active form, 3,3,5-triiodo l-thyronine, T 3 (DIO2), and vice versa (DIO3)

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But you would need to be really committed because there is an increased risk of you relapsing due to the fact that you might have lost a lot of the weight only due to a drug