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One of the physiological substrates of this transporter is acetylcholine, underlying a key role in the non-neuronal cholinergic system in both physiological and pathological conditions, as testified by the occurrence of a natural mutation of OCTN1 in inflammatory conditions such as Crohns Disease (Pochini et al., 2019)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Guyatt G.H., Oxman A.D., Vist G.E., Kunz R., Falck-Ytter Y., Alonso-Coello P., Schnemann H.J., GRADE Working Group GRADE: An emerging consensus on rating quality of evidence and strength of recommendations