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As above, full details and formulas appear in Addition File 1

For ABPP analyses only, outlier samples (based on low precursor identifications or clustering by principle coordinate analysis) were removed, leaving a minimum of 3/4 samples per condition

None of these ranges come from a published human clinical trial of IGF-1 LR3 they are extrapolated from preclinical work, the Increlex (mecasermin) clinical record, and decades of community reporting

Muscle and joint complaints Tirzepatide muscle pain and body aches are reported by a subset of users, and these may recur or change in character when switching between medications