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reduced glutathione, an important intracellular metabolite for regulation, is a prosthetic group of glyceraldehyde phosphate dehydrogenase, is a coenzyme of glyoxalase and triose dehydrogenase, participates in tricarboxylic acid cycle and sugar metabolism in vivo, and can activate various enzymes such as sulfhydryl (-SH) enzyme-coenzyme and the like, thereby promoting carbohydrate, fat and protein metabolism

Conventional approaches using insulin have been proven ineffective, development of new strategies to promote glucose uptake is a promising initiative

Formulation pH is critical: GHK-Cu is most stable at pH 5.06.0

Liraglutide was started at 0.6 mg once daily and up-treated by 0.6 mg every week up to 1.8 mg/day (24 weeks)