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Reported EC values for MT-II in transfected cell assays fall in the sub-nanomolar to low-nanomolar range at MC1R and MC4R, roughly an order of magnitude weaker at MC3R and MC5R, and it is essentially inactive at MC2R, the adrenocorticotropin receptor

The effect of DSIP on GABA receptors and glutamate receptors in neurons of the hypothalamus, thalamus, cortex, hippocampus, and cerebellum has been at least partially attributed to motor function recovery in test subjects [15, 16, 17]

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