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Safety is also dose- and condition-specific: in the LOVIT sepsis trial published in the New England Journal of Medicine (2022), high-dose IV vitamin C was linked to worse outcomes than placebo, which underscores that more is not always better

Methods We searched for eligible trials published in PubMed (last search in February 2015) by using the following search algorithm: (Glucagon-like peptide-1 receptor agonists OR exenatide OR liraglutide OR lixisenatide OR albiglutide OR dulaglutide) AND (side effects OR adverse effects OR safety OR gastrointestinal OR pancreas OR liver OR cardiovascular OR skin OR allergy OR angioedema OR immune system OR renal OR kidney OR infection OR central nervous system OR blood OR malignancy OR cancer) The search was limited by the following criteria: - Published in the English language

This passive targeting mechanism still can be enhanced to make a favourable delivery of antioxidants to the cancer cells making it more efficient

doi: 10.1089/ars.2005.7.1040 126 Babaei-AbrakiSKaramaliFNasr-EsfahaniMH