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Exhibit A: Creators on social media have started documenting what they believe is hair loss associated with GLP-1 use

Ecnoglutide deliberately tilts the GLP-1 receptor toward cyclic-AMP (cAMP) signaling while toning down -arrestin recruitment, a design that preclinical work in cell culture and murine models linked to stronger fat-mass reduction and lean-mass preservation [ScienceDirect]

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So, there is more alcohol available in the system which may reduce the tolerability. Alcohol withdrawal Sudden alcohol withdrawal can lead to characteristic symptoms such as Rapid heartbeat Increased sweating Increased blood pressure Excessive sweating Tremors Seizures Hallucination and delirium Difficulty speaking Anxiety Distress Anhedonia Relapse of heavy drinking may be the result of the inability to cope with alcohol withdrawal