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However, a noticeable effect on weight loss and fat burning will probably take several days to several weeks, depending on the metabolism, age, health, and lifestyle

Rapid fat loss may also affect metabolism

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ACHIEVE-4 (NCT05803421) This trial evaluates orforglipron in patients with type 2 diabetes already treated with basal insulin, assessing whether the addition of an oral GLP-1 agonist can improve glycemic control and reduce insulin requirements