Stress can exacerbate existing psoriasis or even trigger its onset ( Obesity: Adipose tissue in obese individuals can promote the production of pro-inflammatory cytokines, potentially contributing to the chronic inflammation characteristic of psoriasis ( Infections: Some researchers suggest a possible role for infections, particularly those involving streptococcal bacteria, in triggering guttate psoriasis ( Other environmental factors: While the evidence is less conclusive, alcohol consumption and certain medications have also been implicated in psoriasis pathogenesis ( 3.2 Current psoriasis treatment landscape: progress and challenges Psoriasis treatment strategies are tailored to disease severity, patient characteristics, and treatment efficacy and safety profiles ( 3.2.1 Conventional systemic treatments Psoriasis is traditionally treated with methotrexate, a systemic medicine known for its cytotoxic, anti-inflammatory, and immune-modulatory effects, making it therapeutically valuable
00:01:45 Don Weinberger: So before we deep dive into these side effect claims, we should briefly review what these meds are and how they work
Regarding the triple combination, the pathways are highly similar to those of (M+D)/2, with an additional enrichment in pathways associated with anion transmembrane transporter activity ( Figure 7B )
Understanding peptide considerations for women over 40 and age-related factors in perimenopause or menopause adds additional context for this population
