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When the -helices of PrPc refold into -sheets, this gives the pathogenic PrPsc misfolded variants, and then the prion proteins become pathogenic, resulting in neurodegeneration ( 7 Akkermansia , butyrate, GLP-1, diabetes and obesity In this section, we will describe the role that the gut microbes, particularly Akkermansia muciniphila , play in protecting the host from diabetes and obesity, via the release of a protein that induces the secretion of glucagon-like peptide 1 (GLP-1) from intestinal L-cells ( A muciniphila is a commensal bacterium in the human gut that feeds only on the sulfomucins produced by the colonic goblet cells

Few clinical studies have demonstrated the important association of GLP-1 and different food preferences in humans

10.1073/pnas.96.13.7473

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