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2.5.7.3 Duvakitug Duvakitug (TEV-48574) is a fully human IgG1 monoclonal antibody that targets TL1A-DR3 signaling to reduce inflammation and fibrosis in IBD patients, studied in the Phase 2b RELIEVE UCCD trial (NCT05499130) which randomized 290 adults with moderate to severe UC or CD to receive subcutaneous duvakitug (450mg or 900mg every 2 weeks after loading dose) or placebo for 14 weeks across 164 global sites

Pancreatic cancer surgery may reduce digestive enzyme production, which can impair nutrient absorption, so enzyme replacements are typically prescribed to prevent this