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Zhuo, R

10.1186/s13229-021-00472-4 49 EmanueleE.OrsiP.BosoM.BrogliaD.BrondinoN.BaraleF.et al (2010)

Mitochondria, powerhouses of cells, are critical for neuronal survival due to their central role in energy production, calcium buffering, redox balance, and regulation of apoptotic pathways

When there's excessive anything in a given pathway (especially something as toxic as glutamate), the brain responds by reducing sensitivity and/or # of receptors