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ReedSKnezMUzanAStangoulisJCRGlahnRPKorenOet al

Among the most promising candidates, supported by phase 1 and 2 clinical trials, is cagrilintide, a long-acting amylin and calcitonin receptor agonist

This three-test combination reveals the pattern: functional B12 deficiency (elevated MMA with normal B12), combined deficiency (elevated MMA and elevated homocysteine with low B12), or isolated MMA elevation pointing to renal function, gut dysbiosis, low stomach acid, or genetic variants