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Almost all of the evidence is from small trials or animal work, so we dont know about chronic use, safety for offspring, or late adverse effects

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Weisberg et al., in 2006 demonstrated that knocking out C-C chemokine receptor type 2 (CCR2), a crucial MCP-1 receptor, shows decreased adipose tissue macrophage recruitment and inflammatory gene expression and further protected against insulin resistance in HFD models [30]