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The functional relevance of this metabolic shift was confirmed by pharmacological inhibition of mitochondrial respiration, which abolished the survival benefit conferred by cholesterol supplementation, underscoring the central role of mitochondrial metabolism in mediating host protection

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Western blot analysis showed that the protein expression of p53-pS15 in the nuclei of keloid fibroblasts was significantly higher than that in normal skin fibroblasts ( p = 0.01