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Disruption of MET receptor tyrosine kinase, an autism risk factor, impairs developmental synaptic plasticity in the Hippocampus

## Head-to-Head Comparison Table | Feature | Orforglipron | Oral Semaglutide | Tirzepatide (Injectable) | |---------|-------------|-----------------|-------------------------| | **Drug type** | Non-peptide small molecule | Peptide with SNAC enhancer | Peptide (GLP-1/GIP dual agonist) | | **Route** | Oral (daily pill) | Oral (daily tablet) | Subcutaneous injection (weekly) | | **Weight loss** | ~15% (Phase 2/3 data) | ~15.1% (OASIS 1) | 20-22.5% (SURMOUNT-1) | | **Fasting required?** | No | Yes (30+ min empty stomach) | N/A (injection) | | **Food/water restrictions** | None | 4 oz water only

Some also notice their digestion shifting a bit as their body adjusts

For confirmed B12 deficiency without neurological involvement , the standard regimen comprises 1 mg hydroxocobalamin intramuscularly three times weekly for two weeks, followed by maintenance doses every two to three months for those with irreversible causes like pernicious anaemia