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In addition, NAD + production by the NNT enhance SIRT3-mediated deacetylation and loss of NAD + -dependent deacetylase SIRT3 increases the acetylation of IDH2 at K413 and decreases its enzymatic activity by reducing dimerization, thus regulates mitochondrial redox status and promotes cell tumorigenesis in luminal B breast cancer, 137 and B cell malignancies

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GSH reacts directly with (O 2 * - ), hydroxyl radical (OH * ) and organic free radicals and is critical for the detoxification processes of xenobiotic metabolism (Yu, 1994