In addition, a relative insulin deficiency stimulates gluconeogenesis in the liver and lipolysis in the adipose tissue, resulting in the release of glucose and free fatty acids, and, thereby further increasing the levels of circulating energy sources
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Indeed, experimental data confirm that metabolites 1,3-diaminopropane and reuterin inhibit the heterodimerization of HIF-2 with the aryl hydrocarbon receptor nuclear translocator (ARNT) and markedly inhibit tissue iron accumulation in overload models (Das et al., 2020)
