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In 2022, the approval expanded to include adolescents aged 12 and older

Compared to other antidiabetic drugs, including subcutaneously administrated GLP-1R agonists, oral semaglutide is associated with significant improvements in HbA1c levels and body weight of patients with T2D and is either non-inferior or superior in effect

22,23 Obese HFpEF patients have greater LV hypertrophy and pulmonary capillary wedge pressure, increased LV filling pressures and severe right ventricular dysfunction compared with non-obese HFpEF patients

Building on these reference trials, we specified two protocols that expanded eligibility to assess the effectiveness of semaglutide versus sitagliptin and tirzepatide versus dulaglutide in populations reflective of patients routinely seen in clinical practice, spanning low, moderate or high cardiovascular risk (Supplementary Table 26)