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"Safety and Tolerability of the Hexadeca Peptide AOD9604 in Humans." Journal of Endocrinology and Metabolism 3.1-2 (2013): 7-15

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However, studies using recombinant human IGF-1 (rhIGF-1), the native hormone that IGF-1 LR3 mimics more potently, provide the closest human evidence

When combined with semaglutide (as CagriSema), it has demonstrated additive weight loss effects beyond either compound alone