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With respect to retatrutide and the GLP-1 receptor agonist class more broadly, individuals should be aware of the following and seek prompt medical attention if they occur: Severe, persistent upper abdominal pain , with or without vomiting this may indicate pancreatitis, a recognised risk with GLP-1-based therapies, and requires urgent medical assessment [10] Biliary symptoms such as right upper abdominal pain, jaundice, or pale stools gallbladder disease is a known class-associated risk Persistent nausea, vomiting, or abdominal pain that is not resolving Signs of dehydration (dark urine, dizziness, reduced urine output) Unexplained muscle weakness or cramps Symptoms of low blood glucose (shakiness, sweating, confusion) this is most relevant in individuals also taking insulin or sulfonylureas, as retatrutide monotherapy carries a lower inherent risk of hypoglycaemia Anyone who experiences a suspected adverse reaction or product quality concern should report it via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk or via the Yellow Card app

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