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By the studys end, patients in all three tirzepatide groups lost around 4-12 more pounds than the semaglutide group and exhibited better diabetic biomarkers.3 The second was published in JAMA Internal Medicine in 2024

While the location itself does not change effectiveness, repeatedly injecting into the exact same spot can lead to irritation or complications such as lipodystrophy, where the fat under the skin changes in a way that may affect absorption

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Specifically: on one hand, EVs from obese individuals may carry miRNAs and other molecules that regulate insulin signaling, affecting the reduced sensitivity of target cells to insulin