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This feature renders cancer cells more sensitive to external stimuli that further increase the production of ROS 145,146,147 , and, as schematically summarized in Table 1, an increasing number of therapeutic strategies are being developed to elevate ROS levels to overwhelm the redox adaptation of the same cells, inducing oxidative stress incompatible with cellular life 148,149,150,151 (Fig

Mechanism : at optimal dose (1-2 g/day), muscle L-carnitine concentrations increase sufficiently to saturate the "carnitine shuttle," maximizing the flux of fatty acids to the mitochondria

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E., Weiner, O