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This accumulation is mediated by plasmalemmal transporters predominantly expressed in glial cell, such as divalent metal transporter 1 DMT1/SLC11A2 or zinc transporter ZIP14/SLC39A14, 374,375 which both transport Fe 2+ (ferrous), whereas Fe 3+ (ferric) is accumulated through transferrin receptors
A number of these molecules have been shown to exacerbate inflammation through various mechanisms, such as via binding to DAMP receptors like TLR4 (92)
The key is matching the magnesium form to your specific digestive needs and tolerance levels
doi: 10.1038/s41401-021-00801-6 27 GeXJiangFWangMChenMLiYPhippsJet al
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