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In addition to our presence at ASGCT, our senior vice president of translational DMPK and clinical pharmacology, Meena - PhD, presented at the TIDES USA meeting, a forum focused on oligonucleotide, peptide, mRNA, genome editing and delivery innovations

Dropping the 1mg arm acknowledges that while it produced statistically significant weight loss, the magnitude was insufficient for a competitive regulatory filing

Second, larger vials concentrate risk as well as mass, since one contamination event or one mishandled freeze-thaw cycle costs proportionally more material