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Thus, the functional integrity of glutathione metabolism in humans depends primarily on endogenous synthesis and controlled recycling within cells rather than external supplementation

Research suggests it acts through modulation of several interconnected signaling pathways simultaneously a broad mechanism of action that helps explain its observed multisystemic effects in laboratory models, and that also makes it challenging to evaluate through conventional single-target drug development frameworks

This may partly explain why it remains a common ingredient in pre-workout and endurance supplements

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