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Increased temperatures can interfere with testicular thermoregulation, hinder spermatogenesis, and lead to hormonal imbalances, hence diminishing reproductive potential (121)
Certain genes associated with Hashimotos make individuals more susceptible, but environmental factors, such as stress, infections, and dietary influences, often play a pivotal role in triggering the autoimmune response
doi: 10.1128/IAI.01062-06 121 MaciverI.LatimerJ
Moreover, WES allows for the integration of pharmacogenomic information, particularly exonic variants in genes related to the Absorption, Distribution, Metabolism, and Excretion (ADME) of drugs, which may complement targeted assays traditionally used to calculate pharmacogenetic profiles, with the possibility of expanding the understanding of gene-drug interactions, and indirectly inform potential drugdrug and drug-nutrient interactionswhich will necessarily have to be calculated through other platforms (Whirl-Carrillo et al., 2012)
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