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Gastrointestinal Effects The most commonly reported adverse effects are gastrointestinal in nature, including: Nausea and vomiting (affecting 20-40% of patients initially, varying by agent and dose) [8] Diarrhoea or constipation Abdominal discomfort and bloating Reduced appetite In elderly patients, persistent nausea and vomiting can lead to dehydration and electrolyte imbalances more rapidly than in younger adults

Similarly, symptoms of gallbladder diseasesuch as pain in the right upper abdomen, fever, or yellowing of the skin or eyesrequire prompt medical review, as GLP-1 receptor agonists have been associated with an increased risk of gallstones

This suggests that, from a regulatory and pharmacological standpoint, the combination is considered acceptable

7: Your lifestyle is fighting the medication Semaglutide reduces appetite but it does not change what you eat when you do eat