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This sharp rebound occurs because the underlying appetite-regulating effects of the medication wear off, allowing hunger signals and food cravings to resurface

Diabetes Care 39 , 198205 (2016)

Changes in the microbiome in models of polycystic ovary syndrome (PCOS) have been linked to weight reduction, while studies on neurobehavioral effects have revealed lower inflammation in the hippocampus and increased neurogenesis, thereby supporting the involvement of GLP-1RAs in the GBA [48-51]

Lutein may stimulate extracellular signal-regulated kinase (ERK, a mitogen activated protein kinase) and cause the dissociation of Kelch-like ECH-associated protein 1 (Keap1) from the Nrf2/Keap1 complex