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As the first FDA-approved dual incretin receptor agonist, tirzepatide serves as a key reference compound for GIP/GLP-1 synergy research and a benchmark for emerging triple agonist compounds including retatrutide

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Altogether, these proinflammatory changes in vascular homeostasis are known to promote proatherogenic accumulation of both inflammatory leukocytes and LDL in the vascular wall 36 (Fig

Provides consistent mitochondrial support without daily injection burden