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Over 250 patients underwent metabolomics and lipidomic investigations, which revealed that unlike the baseline and placebo, tirzepatide, taken over 26 weeks, significantly impacted a group of lipids and metabolites like 3-hydroxybutyrate reduced branched-chain ketoacids (BCKA), branched-chain amino acids (BCAA), and direct catabolic products linked with obesity and insulin resistance

usually thrown in for detox branding rather than any proven effect

The trial was also not randomized or controlled, two serious marks against it

FYI: Retatrutide is also being studied as a type 2 diabetes treatment, where it's shown impressive results for both blood sugar control and weight loss