Deficiency of vitamin B12 can lead to abnormal neurologic and psychiatric symptoms including ataxia (shaky movements and unsteady gait), muscle weakness, spasticity, incontinence, hypotension, vision problems, dementia, psychoses, and mood disturbances BENEFITS OF B12: More energy, mental alertness and stamina for everyday tasks Healthier immune systems Improves sleep Increases metabolism, thereby aiding in weight loss Reduces allergies, stress and depression Improves mood stabilization Lessens frequency and severity of migraines and headaches Helps lower homocysteine levels in the blood, thereby reducing the probability of heart diseases and strokes POSSIBLE SIDE EFFECTS AND CONTRADICTIONS OF B12: A vitamin B12 shot is safe and generally has no side effects, even in higher doses

However, in terms of clinical translation most gene and cell therapy strategies are still in early stages of a complex developmental process that involves extensive research and caution prior to widespread human application
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Cognitive behavioral therapy for lifestyle changes in patients with obesity and type 2 diabetes: a systematic review and meta-analysis