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Modulation of visceral pain by brain nuclei and brain circuits and the role of acupuncture: a narrative review

*Correspondence: Joo Sargento-Freitas [email protected] This article was submitted to Stroke, a section of the journal Frontiers in Neurology These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This apparent discrepancy is not uncommon for this type of compound as similar results have been previously reported for ellagic acid, which displays 100 fold higher potency against parasites than against the purified GST enzyme, with a Ki of 74 M in an enzyme assay but an EC 50 of 0.8 M in antiparasitic assays (Sturm et al., 2009)

Clinical trials show an average weight loss of around 21%