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Documented weight loss results from the SURMOUNT-1 trial showed average losses of 34.4 pounds at the 5mg dose, 49 pounds at the 10mg dose, and 52 pounds at the 15mg dose over 72 weeks

Tirzepatide (as Mounjaro or Zepbound) is approved for type 2 diabetes and/or weight management in the following countries: Additionally, in December 2024, the United States FDA revised the indication for tirzepatide (branded as Zepbound) to include the treatment of moderate to severe obstructive sleep apnea

The article says DPP-4 inhibitors such as sitagliptin, saxagliptin and linagliptin block the enzyme that breaks down the incretin hormones GLP-1 and GIP, which raises native GLP-1 levels in the bloodstream

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