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9B, D), which reflected elevated hippocampal intracellular calcium levels in MSG-exposed rats, previous studies have linked the high intracellular calcium levels induced by excessive glutaminergic stimulation with increased caspase activation and neuronal cell death in the pathological cascades of numerous neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), PD, and AD 8
USA 104 , 68286833 (2007)
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Therefore, inhibition of mTORC1 pathway and the induction of ISR may conceivably contribute to the pathological conditions related to cysteine deficiency
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