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129 Amaya et al

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The combined effect of these modifications increase the drugs half-life from minutes to approximately 168 hours, enabling its once-weekly injection schedule an enormous improvement compared to the twice daily injection required for exenatide (Byetta) which was the first GLP-1 drug that was launched.1 Semaglutide (under the brand names Ozempic and Wegovy) swept the market

doi: 10.1002/(sici)1097-0215(19970926)73:1 3.0.co;2-5