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Figure 3: Percentage of DPNP Adult Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity (Study DPNP-1) Figure 4: Percentage of DPNP Adult Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity (Study DPNP-2) Adult Trials in Fibromyalgia The efficacy of CYMBALTA for the management of fibromyalgia in adults was established in two randomized, double-blind, placebo-controlled, fixed-dose trials in adult patients meeting the American College of Rheumatology criteria for fibromyalgia (a history of widespread pain for 3 months, and pain present at 11 or more of the 18 specific tender point sites)

However, it is not recommended for those with severe liver conditions

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Mutations in SLC30A10 , which encodes ZNT10, also cause hypermanganesemia, with elevated Mn levels in the blood and brain