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Increasing cellular nad+ Protects hepatocytes against palmitate-induced lipotoxicity by preventing parp-1 inhibition and the mtorc1-P300 pathway activation

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Subsequent studies by the same research team found that microglia develop a senescence-like phenotype after engulfing NFT-containing neurons, and they release toxic forms of partially digested tau (74)

Instead, a small pattern of genes mapping to innate immunity and antiviral activity required GSH for their induction