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Additionally, gaining approval for obesity treatment, especially in non-diabetic populations, can be more stringent due to concerns over long-term safety and cost-effectiveness

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The recently published randomised controlled Study of Tirzepatide Compared with Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT) demonstrated that tirzepatide (up to 15 mg) was non-inferior to dulaglutide (1.5 mg) in reducing major adverse cardiovascular events (death from cardiovascular causes, myocardial infarction or stroke) in patients with T2DM and atherosclerotic CVD

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