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less commonly used in adults Partial enteral nutrition may supplement medical therapy and support nutritional status Total parenteral nutrition (TPN) indicated for severe malnutrition, short bowel syndrome post-resection, or surgical preparation 17

A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

At the 10mg/ml concentration, the 50-unit draw is cleaner and more comfortable for the 5mg dose