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The added b12 makes a huge difference

If youve tolerated the lower doses well, prescribers typically recommend the 15mg maintenance dose from week 21 onwards

Lack of these two proteins can prevent lysosomal biogenesis and autophagosome maturity, leading to the ganglioside accumulation and neuronal death 124

If you are on the fence about whether you can keep going past a few months, my experience says yes