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How might a diabetes drug help treat Parkinsons

That's peanuts," Trump said of their US manufacturing investments

in August of 1984

The structural basis for orforglipron's mechanism was published in the Proceedings of the National Academy of Sciences in 2020, revealing through cryo-electron microscopy (cryo-EM) how a small molecule could stabilize the active conformation of a class B GPCR, a finding that fundamentally changed the field's understanding of GPCR pharmacology