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Patients should be educated on recognising hypoglycaemic symptoms (sweating, tremor, confusion, palpitations) and the importance of carrying fast-acting carbohydrates

MiR-145, a well-known tumor suppressor miRNA, is substantially downregulated in tumor tissues relative to their equivalent normal tissues in prostate and breast cancer [117]

In such cases, no treatment is generally required If required, a surgical excision and complete removal of the macule, primarily to address cosmetic issues may be undertaken Cryotherapy, intense pulsed light (IPL), or laser therapy may be therapeutic Treatment of the underlying associated genetic disorder, if any Follow-up care with regular screening and check-ups are encouraged How can Genital Melanotic Macules be Prevented